CC-interop : COPAC/Clumps Continuing Technical Cooperation. Final Project Report

As far as is known, CC-interop was the first project of its kind anywhere in the world and still is. Its basic aim was to test the feasibility of cross-searching between physical and virtual union catalogues, using COPAC and the three functioning "clumps" or virtual union catalogues (CAIRNS, InforM25, and RIDING), all funded or part-funded by JISC in recent years. The key issues investigated were technical interoperability of catalogues, use of collection level descriptions to search union catalogues dynamically, quality of standards in cataloguing and indexing practices, and usability of union catalogues for real users. The conclusions of the project were expected to, and indeed do, contribute to the development of the JISC Information Environment and to the ongoing debate as to the feasibility and desirability of creating a national UK catalogue. They also inhabit the territory of collection level descriptions (CLDs) and the wider services of JISC's Information Environment Services Registry (IESR). The results of this project will also have applicability for the common information environment, particularly through the landscaping work done via SCONE/CAIRNS. This work is relevant not just to HE and not just to digital materials, but encompasses other sectors and domains and caters for print resources as well. Key findings are thematically grouped as follows: System performance when inter-linking COPAC and the Z39.50 clumps. The various individual Z39.50 configurations permit technical interoperability relatively easily but only limited semantic interoperability is possible. Disparate cataloguing and indexing practices are an impairment to semantic interoperability, not just for catalogues but also for CLDs and descriptions of services (like those constituting JISC's IESR). Creating dynamic landscaping through CLDs: routines can be written to allow collection description databases to be output in formats that other UK users of CLDs, including developers of the JISC information environment. Searching a distributed (virtual) catalogue or clump via Z39.50: use of Z39.50 to Z39.50 middleware permits a distributed catalogue to be searched via Z39.50 from such disparate user services as another virtual union catalogue or clump, a physical union catalogue like COPAC, an individual Z client and other IE services. The breakthrough in this Z39.50 to Z39.50 conundrum came with the discovery that the JISC-funded JAFER software (a result of the 5/99 programme) meets many of the requirements and can be used by the current clumps services. It is technically possible for the user to select all or a sub-set of available end destination Z39.50 servers (we call this "landscaping") within this middleware. Comparing results processing between COPAC and clumps. Most distributed services (clumps) do not bring back complete results sets from associated Z servers (in order to save time for users). COPAC on-the-fly routines could feasibly be applied to the clumps services. An automated search set up to repeat its query of 17 catalogues in a clump (InforM25) hourly over nearly 3 months returned surprisingly good results; for example, over 90% of responses were received in less than one second, and no servers showed slower response times in periods of traditionally heavy OPAC use (mid-morning to early evening). User behaviour when cross-searching catalogues: the importance to users of a number of on-screen features, including the ability to refine a search and clear indication that a search is processing. The importance to users of information about the availability of an item as well as the holdings data. The impact of search tools such as Google and Amazon on user behaviour and the expectations of more information than is normally available from a library catalogue. The distrust of some librarians interviewed of the data sources in virtual union catalogues, thinking that there was not true interoperability

Runs of homozygosity and testicular cancer risk

Background: Testicular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has long alluded to recessively acting TGCT genetic susceptibility factors, but to date none have been reported. Runs of homozygosity (RoH) are a signature indicating underlying recessively acting alleles and have been associated with increased risk of other cancer types. / Objective: To examine whether RoH are associated with TGCT risk. / Methods: We performed a genome‐wide RoH analysis using GWAS data from 3206 TGCT cases and 7422 controls uniformly genotyped using the OncoArray platform. / Results: Global measures of homozygosity were not significantly different between cases and controls, and the frequency of individual consensus RoH was not significantly different between cases and controls, after correction for multiple testing. RoH at three regions, 11p13‐11p14.3, 5q14.1‐5q22.3 and 13q14.11‐13q.14.13, were, however, nominally statistically significant at p < 0.01. Intriguingly, RoH200 at 11p13‐11p14.3 encompasses Wilms tumour 1 (WT1), a recognized cancer susceptibility gene with roles in sex determination and developmental transcriptional regulation, processes repeatedly implicated in TGCT aetiology. / Discussion and conclusion: Overall, our data do not support a major role in the risk of TGCT for recessively acting alleles acting through homozygosity, as measured by RoH in outbred populations of cases and controls

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Point-of-care testing in paediatric settings in the UK and Ireland: A cross-sectional study

Background: Point-of-care testing (POCT) is diagnostic testing performed at or near to the site of the patient. Understanding the current capacity, and scope, of POCT in this setting is essential in order to respond to new research evidence which may lead to wide implementation. Methods: A cross-sectional online survey study of POCT use was conducted between 6th January and 2nd February 2020 on behalf of two United Kingdom (UK) and Ireland-based paediatric research networks (Paediatric Emergency Research UK and Ireland, and General and Adolescent Paediatric Research UK and Ireland). Results: In total 91/109 (83.5%) sites responded, with some respondents providing details for multiple units on their site based on network membership (139 units in total). The most commonly performed POCT were blood sugar (137/139; 98.6%), urinalysis (134/139; 96.4%) and blood gas analysis (132/139; 95%). The use of POCT for Influenza/Respiratory Syncytial Virus (RSV) (45/139; 32.4%, 41/139; 29.5%), C-Reactive Protein (CRP) (13/139; 9.4%), Procalcitonin (PCT) (2/139; 1.4%) and Group A Streptococcus (5/139; 3.6%) and was relatively low. Obstacles to the introduction of new POCT included resources and infrastructure to support test performance and quality assurance. Conclusion: This survey demonstrates significant consensus in POCT practice in the UK and Ireland but highlights specific inequity in newer biomarkers, some which do not have support from national guidance. A clear strategy to overcome the key obstacles of funding, evidence base, and standardising variation will be essential if there is a drive toward increasing implementation of POCT

CC-interop: COPAC/Clumps Continuing Technical Cooperation. Final Project Report

As far as is known, CC-interop was the first project of its kind anywhere in the world and still is. Its basic aim was to test the feasibility of cross-searching between physical and virtual union catalogues, using COPAC and the three functioning "clumps" or virtual union catalogues (CAIRNS, InforM25, and RIDING), all funded or part-funded by JISC in recent years. The key issues investigated were technical interoperability of catalogues, use of collection level descriptions to search union catalogues dynamically, quality of standards in cataloguing and indexing practices, and usability of union catalogues for real users. The conclusions of the project were expected to, and indeed do, contribute to the development of the JISC Information Environment and to the ongoing debate as to the feasibility and desirability of creating a national UK catalogue. They also inhabit the territory of collection level descriptions (CLDs) and the wider services of JISC's Information Environment Services Registry (IESR). The results of this project will also have applicability for the common information environment, particularly through the landscaping work done via SCONE/CAIRNS. This work is relevant not just to HE and not just to digital materials, but encompasses other sectors and domains and caters for print resources as well. Key findings are thematically grouped as follows: System performance when inter-linking COPAC and the Z39.50 clumps. The various individual Z39.50 configurations permit technical interoperability relatively easily but only limited semantic interoperability is possible. Disparate cataloguing and indexing practices are an impairment to semantic interoperability, not just for catalogues but also for CLDs and descriptions of services (like those constituting JISC's IESR). Creating dynamic landscaping through CLDs: routines can be written to allow collection description databases to be output in formats that other UK users of CLDs, including developers of the JISC information environment. Searching a distributed (virtual) catalogue or clump via Z39.50: use of Z39.50 to Z39.50 middleware permits a distributed catalogue to be searched via Z39.50 from such disparate user services as another virtual union catalogue or clump, a physical union catalogue like COPAC, an individual Z client and other IE services. The breakthrough in this Z39.50 to Z39.50 conundrum came with the discovery that the JISC-funded JAFER software (a result of the 5/99 programme) meets many of the requirements and can be used by the current clumps services. It is technically possible for the user to select all or a sub-set of available end destination Z39.50 servers (we call this "landscaping") within this middleware. Comparing results processing between COPAC and clumps. Most distributed services (clumps) do not bring back complete results sets from associated Z servers (in order to save time for users). COPAC on-the-fly routines could feasibly be applied to the clumps services. An automated search set up to repeat its query of 17 catalogues in a clump (InforM25) hourly over nearly 3 months returned surprisingly good results; for example, over 90% of responses were received in less than one second, and no servers showed slower response times in periods of traditionally heavy OPAC use (mid-morning to early evening). User behaviour when cross-searching catalogues: the importance to users of a number of on-screen features, including the ability to refine a search and clear indication that a search is processing. The importance to users of information about the availability of an item as well as the holdings data. The impact of search tools such as Google and Amazon on user behaviour and the expectations of more information than is normally available from a library catalogue. The distrust of some librarians interviewed of the data sources in virtual union catalogues, thinking that there was not true interoperability

An Instrument for the Dynamic Position Measurement of Robot Arms Using a Laser Triangulation Method.

The dynamic performance evaluation of robots has proved difficult because of a lack of suitable measurement equipment. This thesis describes a novel instrument for the dynamic position measurement of industrial robots. The instrument consists of a retro-reflective target that may be attached to any point of the robot arm and two stationary measurement subsystems. Each sub-system generates a laser beam which follows the target. By simultaneously recording the positions of these beams and the distances from their centres to a known point on the target, sufficient information may be obtained for the subsequent off-line calculation of target position. A single measurement sub-system, which includes all of the components present within the complete instrument, has been designed, constructed and tested. Its optical, geometric and control requirements are discussed, and its interface to a micro-computer system is described. Both state-space methods and classical control techniques have been employed in the design of the controller; the unique features of which are its two modes of operation (distinguished by whether the system is tracking the target or not) and its ability to rapidly switch between them. Results are presented showing recordings of the end effector trajectory of a pneumatic point-to-point robot as it moves in a vertical plane at normal operating speeds. In addition, a precision servo-driven linear-motion device has been used for calibration purposes. These tests show that the instrument can record robot movements with speeds of up to 1.5m/s at a maximum sampling rate of 3.47kHz. Its accuracy (without signal averaging) is +0.7mm horizontally and +2.2mm vertically. Greater precision was not possible owing to problems of electrical interference within the circuitry of the prototype instrument

An Instrument for the Dynamic Position Measurement of Robot Arms Using a Laser Triangulation Method.

The dynamic performance evaluation of robots has proved difficult because of a lack of suitable measurement equipment. This thesis describes a novel instrument for the dynamic position measurement of industrial robots. The instrument consists of a retro-reflective target that may be attached to any point of the robot arm and two stationary measurement subsystems. Each sub-system generates a laser beam which follows the target. By simultaneously recording the positions of these beams and the distances from their centres to a known point on the target, sufficient information may be obtained for the subsequent off-line calculation of target position. A single measurement sub-system, which includes all of the components present within the complete instrument, has been designed, constructed and tested. Its optical, geometric and control requirements are discussed, and its interface to a micro-computer system is described. Both state-space methods and classical control techniques have been employed in the design of the controller; the unique features of which are its two modes of operation (distinguished by whether the system is tracking the target or not) and its ability to rapidly switch between them. Results are presented showing recordings of the end effector trajectory of a pneumatic point-to-point robot as it moves in a vertical plane at normal operating speeds. In addition, a precision servo-driven linear-motion device has been used for calibration purposes. These tests show that the instrument can record robot movements with speeds of up to 1.5m/s at a maximum sampling rate of 3.47kHz. Its accuracy (without signal averaging) is +0.7mm horizontally and +2.2mm vertically. Greater precision was not possible owing to problems of electrical interference within the circuitry of the prototype instrument

Study of deformation characteristics of the Donkin-Morien tunnel development

The access tunnels for the Donkin-Morien Mine in Cape Breton, Nova Scotia comprise two parallel tunnels driven through a sedimentary sequence of sandstone, siltstone and mudstone to intersect the Harbour Coal Seam under the Atlantic Ocean, approximately 3.5 km offshore.During the period May 1983 to December 1984, a geotechnical research programme was carried out in the Donkin-Morien tunnels by Golder Associates Ltd. The research programme included the monitoring of the performance of the TBM and drill and blast drivages, and the study of the thrusting characteristics and rock-interaction of the TBM excavation. The main emphasis of the research programme was on the collection of field data, which was to be made available in the form of a comprehensive report. The information gained from the programme was also used during the tunnel drivages to monitor the performance of the installed support and enable changes in the support and advance methods.Throughout the research programme the author was resident on site at the Donkin-Morien Mine and was responsible for all aspects of the research project

The appellation of John Knox from the cruell and most injust sentence pronounced against him by the fasle bishoppes and clergie of Scotland, with his supplication and exhortatione to the nobilitie, and communalite of the same realme.

GLN-1634Baskerville, Polemic published in English, 1558/8CDM, p. 36Gilmont, Bibl. Crespin, n° 58/12*Shaw, Cathedral Libr., 2, K 173STC Edinburgh, p. 202STC, n° 1506